Sunresin Seplife resins include a wide range of chromatographic media designed to deliver exceptional purity, efficiency, and scalability in antibody production, meeting the demands of the biopharmaceutical industry. Whether you're optimizing your downstream process or scaling up for commercial production, our innovative affinity , ion exchange. multimodal and gel filtration resins will enhance yield, streamline workflows, and ensure consistent results.

Platform purification of monoclonal antibodies typically involves a series of chromatography steps designed to maximize yield and purity. The process typically begins with Protein A affinity chromatography , a highly selective method that leverages Protein A ligands to capture antibodies based on their affinity for the Fc region. This step provides robust initial purification, removing the majority of impurities. Following this, Ion Exchange Chromatography (IEX) is used to further purify the antibody based on its charge properties, enabling the separation of remaining contaminants such as host cell proteins and nucleic acids. Finally, Multimodal Chromatography  employs a combination of different binding interactions, including hydrophobic, ionic, and hydrogen bonding, to remove stubborn impurities and aggregates, offering enhanced flexibility and robustness. This platform approach ensures a high-purity final product, suitable for downstream formulation and clinical applications.